Plasma Concentrations of Matrilysins MMP-7 and MMP-26 as Diagnostic Biomarkers in Breast Cancer

Metalloproteinases (MMPs) are a group of proteolytic enzymes involved in the maintenance proper structure extracellular matrix (ECM). Matrilysins (MMP-7 and MMP-26) members MMPs that show promise as potential breast cancer (BC) markers. The aim study was to evaluate plasma levels MMP-7, MMP-26 CA 15-3 individually combination assess diagnostic utility studied matrilysins patients with BC. consisted 120 BC, control 40 subjects benign healthy women. Concentrations MMP-7 were determined by enzyme-linked immunosorbent assay, chemiluminescent microparticle immunoassay. Plasma significantly higher BC than group. highest stages II IV disease. sensitivity observed III for all tested markers (92.5%). specificity noted parameters combined (95.0%). area under receiver operating characteristic (ROC) curve (AUC) (MMP-7+MMP-26+CA 15-3) largest (0.9138) IV. Individual marker analysis showed had AUC (0.8894) advanced Study results indicate could be used an additional would improve early Therefore, assessment might useful determining disease progression. Further studies needed whether improving diagnosis